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Jimmy Adams made the highest post-war score by a Hampshire captain as his side took complete control on day two against Worcestershire at the Rose Bowl.
Resuming overnight on 151, Adams progressed to a double-ton and eventually finished 219 not out from 382 balls - as Hampshire declared on 500 for nine, their largest total against Worcestershire.
The visitors were 159 for five in reply by stumps with both James Tomlinson and David Balcombe taking two wickets as only Moeen Ali offered any prolonged resistance.
In the morning session, Adams and Chris Wood prospered after resuming with the score reading 357 for six.
Wood was eventually caught behind off Daryl Mitchell, ending a seventh-wicket partnership of 96.
New batsman Balcombe departed soon after for a duck, trapped in front by a yorker from Richard Jones to leave Hampshire 448 for eight.
Adams brought up his double-hundred from 357 balls and eventually declared the innings closed after Danny Briggs had added 14 and last man James Tomlinson had top-edged a ball into his own face.
Chasing 351 to avoid the follow-on, Worcestershire's openers Mitchell and Matthew Pardoe began in careful fashion as the home bowlers kept a disciplined line and length.
The score had moved to 40 by the time Balcombe had Mitchell well held at second slip by Liam Dawson.
Pardoe and number three Moeen combined to grind out 24 runs in almost 20 overs, with the bowling side applying further pressure.
Not long after the tea break, Pardoe's patient innings of 29 from 99 balls was brought to an end as he was caught by Vince off Tomlinson.
Overseas player Thilan Samaraweera was the next man in and the next to depart when he edged Wood to Sean Ervine at first slip, leaving Worcestershire struggling on 98 for three.
A period of consolidation was necessary, but Alexei Kervezee threw his wicket away in horrendous fashion just three overs later, lofting Balcombe high to Briggs.
At the other end Moeen looked in superb nick, adding a chanceless half-century to impressive figures of 4-103 in Hampshire's first-innings.
Yet he too gave his wicket away to a loose shot, hitting Tomlinson hard to Dawson at second slip on 55.
Sixth-wicket pair Neil Pinner and Michael Johnson survived until the close, but Hampshire - who still lead by 341 runs - remained clear favourites for a comprehensive win.
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